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Effects of Photo-chemically Activated Alkylating Agents of the FR900482 Family on Chromatin
Bioreductive alkylating agents are an important class of clinical antitumor antibiotics that cross-link and mono-alkylate DNA. Here we use a synthetic photochemically activated derivative of FR400482 to investigate the molecular mechanism of this class of drugs in a biologically relevant context. We...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097141/ https://ncbi.nlm.nih.gov/pubmed/17524986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.04.004 |
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