Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility

INTRODUCTION: Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation and promotes maturation of osteoblasts. RUNX2 expression is inversely regulated with respect to cell growth in osteoblasts and deregulated in osteos...

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Detalhes bibliográficos
Main Authors: Leong, David T, Lim, Joleen, Goh, Xuewei, Pratap, Jitesh, Pereira, Barry P, Kwok, Hui Si, Nathan, Saminathan Suresh, Dobson, Jason R, Lian, Jane B, Ito, Yoshiaki, Voorhoeve, P Mathijs, Stein, Gary S, Salto-Tellez, Manuel, Cool, Simon M, van Wijnen, Andre J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096982/
https://ncbi.nlm.nih.gov/pubmed/21029421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2762
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