GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways

NGF initiates the majority of its neurotrophic effects by promoting the activation of the tyrosine kinase receptor TrkA. Here we describe a novel interaction between TrkA and GIPC, a PDZ domain protein. GIPC binds to the juxtamembrane region of TrkA through its PDZ domain. The PDZ domain of GIPC als...

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Main Authors: Lou, Xiaojing, Yano, Hiroko, Lee, Francis, Chao, Moses V., Farquhar, Marilyn Gist
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2001
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC30968/
https://ncbi.nlm.nih.gov/pubmed/11251075
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