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Coordination of DNA–PK Activation and Nuclease Processing of DNA Termini in NHEJ

DNA double-strand breaks (DSB), particularly those induced by ionizing radiation (IR), are complex lesions that can be cytotoxic if not properly repaired. IR-induced DSB often have DNA termini modifications, including thymine glycols, ring fragmentation, 3′-phosphoglycolates, 5′-hydroxyl groups, and...

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Bibliografske podrobnosti
Main Authors: Pawelczak, Katherine S, Bennett, Sara M, Turchi, John J
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096510/
https://ncbi.nlm.nih.gov/pubmed/20698792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3368
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