STAT-Phosphorylation–Independent Induction of Interferon Regulatory Factor-9 by Interferon-β

Type I interferon (IFN)-dependent STAT1 and STAT2 activation requires specific tyrosine residues (337Y and 512Y) located in the cytoplasmic domain of IFNAR-2c, the β-subunit of the human type I IFN receptor. To identify STAT activation-independent induction of ISGs, we used a mutant cell line in whi...

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Autores principales: Rani, M.R. Sandhya, Croze, Ed, Wei, Tao, Shrock, Jennifer, Josyula, Anupama, Kalvakolanu, Dhananjaya V., Ransohoff, Richard M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. publishers 2010
Materias:
Research Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096491/
https://ncbi.nlm.nih.gov/pubmed/20038197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2009.0032
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