An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 Envelopes

While CCR5 is the principal coreceptor used by macrophage (M)-tropic HIV-1, not all primary CCR5-using (R5) viruses enter macrophages efficiently. Here, we used functionally-diverse R5 envelope (Env) clones to characterize virus-cell interactions important for efficient CCR5-mediated macrophage entr...

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Main Authors: Sterjovski, Jasminka, Roche, Michael, Churchill, Melissa J., Ellett, Anne, Farrugia, William, Gray, Lachlan R., Cowley, Daniel, Poumbourios, Pantelis, Lee, Benhur, Wesselingh, Steven L., Cunningham, Anthony L., Ramsland, Paul A., Gorry, Paul R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096480/
https://ncbi.nlm.nih.gov/pubmed/20570309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.05.006
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