Genetic predictors of fibrin D-dimer levels in healthy adults

BACKGROUND: Fibrin fragment D-dimer is one of several peptides produced when cross-linked fibrin is degraded by plasmin, and is the most widely-used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide as...

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Bibliografiske detaljer
Main Authors: Smith, Nicholas L., Huffman, Jennifer E., Strachan, David P., Huang, Jie, Dehghan, Abbas, Trompet, Stella, Lopez, Lorna M., Shin, So-Youn, Baumert, Jens, Vitart, Veronique, Bis, Joshua C., Wild, Sarah H., Rumley, Ann, Yang, Qiong, Uitterlinden, Andre G, Stott, David. J., Davies, Gail, Carter, Angela M., Thorand, Barbara, Polašek, Ozren, McKnight, Barbara, Campbell, Harry, Rudnicka, Alicja R., Chen, Ming-Huei, Buckley, Brendan M., Harris, Sarah E., Williams, Frances M. K., Peters, Annette, Pulanic, Drazen, Lumley, Thomas, de Craen, Anton J.M., Liewald, David C., Gieger, Christian, Campbell, Susan, Ford, Ian, Gow, Alan J., Luciano, Michelle, Porteous, David J., Guo, Xiuqing, Sattar, Naveed, Tenesa, Albert, Cushman, Mary, Slagboom, P. Eline, Visscher, Peter M., Spector, Tim D., Illig, Thomas, Rudan, Igor, Bovill, Edwin G., Wright, Alan F., McArdle, Wendy L., Tofler, Geoffrey, Hofman, Albert, Westendorp, Rudi G.J., Starr, John M., Grant, Peter J., Karakas, Mahir, Hastie, Nicholas D., Psaty, Bruce M., Wilson, James F., Lowe, Gordon D. O., O’Donnell, Christopher J, Witteman, Jacqueline CM, Jukema, J. Wouter, Deary, Ian J., Soranzo, Nicole, Koenig, Wolfgang, Hayward, Caroline
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095913/
https://ncbi.nlm.nih.gov/pubmed/21502573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.009480
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