Genetic predictors of fibrin D-dimer levels in healthy adults

BACKGROUND: Fibrin fragment D-dimer is one of several peptides produced when cross-linked fibrin is degraded by plasmin, and is the most widely-used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide as...

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Κύριοι συγγραφείς: Smith, Nicholas L., Huffman, Jennifer E., Strachan, David P., Huang, Jie, Dehghan, Abbas, Trompet, Stella, Lopez, Lorna M., Shin, So-Youn, Baumert, Jens, Vitart, Veronique, Bis, Joshua C., Wild, Sarah H., Rumley, Ann, Yang, Qiong, Uitterlinden, Andre G, Stott, David. J., Davies, Gail, Carter, Angela M., Thorand, Barbara, Polašek, Ozren, McKnight, Barbara, Campbell, Harry, Rudnicka, Alicja R., Chen, Ming-Huei, Buckley, Brendan M., Harris, Sarah E., Williams, Frances M. K., Peters, Annette, Pulanic, Drazen, Lumley, Thomas, de Craen, Anton J.M., Liewald, David C., Gieger, Christian, Campbell, Susan, Ford, Ian, Gow, Alan J., Luciano, Michelle, Porteous, David J., Guo, Xiuqing, Sattar, Naveed, Tenesa, Albert, Cushman, Mary, Slagboom, P. Eline, Visscher, Peter M., Spector, Tim D., Illig, Thomas, Rudan, Igor, Bovill, Edwin G., Wright, Alan F., McArdle, Wendy L., Tofler, Geoffrey, Hofman, Albert, Westendorp, Rudi G.J., Starr, John M., Grant, Peter J., Karakas, Mahir, Hastie, Nicholas D., Psaty, Bruce M., Wilson, James F., Lowe, Gordon D. O., O’Donnell, Christopher J, Witteman, Jacqueline CM, Jukema, J. Wouter, Deary, Ian J., Soranzo, Nicole, Koenig, Wolfgang, Hayward, Caroline
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2011
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095913/
https://ncbi.nlm.nih.gov/pubmed/21502573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.009480
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