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hTID-1 defines a novel regulator of c-Met Receptor signaling in renal cell carcinomas

The c-Met receptor tyrosine kinase (MetR) is frequently overexpressed and constitutively phosphorylated in a number of human malignancies. Activation of the receptor by its ligand, hepatocyte growth factor (HGF), leads to increased cell proliferation, motility, survival and disruption of adherens ju...

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Autors principals: Copeland, E, Balgobin, S, Lee, C M, Rozakis-Adcock, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095899/
https://ncbi.nlm.nih.gov/pubmed/21242965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.601
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