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Tyrosine kinase inhibitors: Multi-targeted or single-targeted?

Since in most tumors multiple signaling pathways are involved, many of the inhibitors in clinical development are designed to affect a wide range of targeted kinases. The most important tyrosine kinase families in the development of tyrosine kinase inhibitors are the ABL, SCR, platelet derived growt...

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Hlavní autoři: Broekman, Fleur, Giovannetti, Elisa, Peters, Godefridus J
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Co., Limited 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095472/
https://ncbi.nlm.nih.gov/pubmed/21603317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5306/wjco.v2.i2.80
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