Site-Directed Mutagenesis of HIV-1 vpu Gene Demonstrates Two Clusters of Replication-Defective Mutants with Distinct Ability to Down-Modulate Cell Surface CD4 and Tetherin

HIV-1 Vpu acts positively on viral infectivity by mediating CD4 degradation in endoplasmic reticulum and enhances virion release by counteracting a virion release restriction factor, tetherin. In order to define the impact of Vpu activity on HIV-1 replication, we have generated a series of site-spec...

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Detalhes bibliográficos
Main Authors: Nomaguchi, Masako, Doi, Naoya, Fujiwara, Sachi, Fujita, Mikako, Adachi, Akio
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2010
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095391/
https://ncbi.nlm.nih.gov/pubmed/21607084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2010.00116
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