Natural Single-Nucleotide Polymorphisms in the 3′ Region of the HIV-1 pol Gene Modulate Viral Replication Ability

We previously showed that prototype macaque-tropic human immunodeficiency virus type 1 (HIV-1) acquired nonsynonymous growth-enhancing mutations within a narrow genomic region during the adaptation process in macaque cells. These adaptive mutations were clustered in the 3′ region of the pol gene, en...

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Bibliographische Detailangaben
Hauptverfasser: Nomaguchi, Masako, Miyake, Ariko, Doi, Naoya, Fujiwara, Sachi, Miyazaki, Yasuyuki, Tsunetsugu-Yokota, Yasuko, Yokoyama, Masaru, Sato, Hironori, Masuda, Takao, Adachi, Akio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993728/
https://ncbi.nlm.nih.gov/pubmed/24478432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01859-13
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