Sequential Immunization with a Subtype B HIV-1 Envelope Quasispecies Partially Mimics the In Vivo Development of Neutralizing Antibodies

A major goal of human immunodeficiency virus type 1 (HIV-1) vaccine efforts is the design of Envelope (Env)-based immunogens effective at eliciting heterologous or broad neutralizing antibodies (NAbs). We hypothesized that programming the B-cell response could be achieved by sequentially exposing th...

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Main Authors: Malherbe, Delphine C., Doria-Rose, Nicole A., Misher, Lynda, Beckett, Travis, Puryear, Wendy Blay, Schuman, Jason T., Kraft, Zane, O'Malley, Jean, Mori, Motomi, Srivastava, Indresh, Barnett, Susan, Stamatatos, Leonidas, Haigwood, Nancy L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094990/
https://ncbi.nlm.nih.gov/pubmed/21430056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02419-10
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