Three Amino Acid Mutations (F51L, T59A, and S390L) in the Capsid Protein of the Hepatitis E Virus Collectively Contribute to Virus Attenuation

Hepatitis E virus (HEV) is an important but extremely understudied human pathogen, and the mechanisms of HEV replication and pathogenesis are largely unknown. We previously identified an attenuated genotype 3 HEV mutant (pSHEV-1) containing three unique amino acid mutations (F51L, T59A, and S390L) i...

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Detalhes bibliográficos
Main Authors: Córdoba, Laura, Huang, Yao-Wei, Opriessnig, Tanja, Harral, Kylie K., Beach, Nathan M., Finkielstein, Carla V., Emerson, Suzanne U., Meng, Xiang-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094989/
https://ncbi.nlm.nih.gov/pubmed/21450834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02278-10
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