Schistosoma mansoni U6 gene promoter-driven short hairpin RNA induces RNA interference in human fibrosarcoma cells and schistosomules

RNA interference (RNAi) mediated by short hairpin-RNA (shRNA) expressing plasmids can induce specific and long-term knockdown of specific mRNAs in eukaryotic cells. To develop a vector-based RNAi model for Schistosoma mansoni, the schistosome U6 gene promoter was employed to drive expression of shRN...

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Bibliografiske detaljer
Main Authors: Ayuk, Mary A., Suttiprapa, Sutas, Rinaldi, Gabriel, Mann, Victoria H., Lee, Clarence M., Brindley, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094803/
https://ncbi.nlm.nih.gov/pubmed/21447344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpara.2011.02.004
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