Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea

This study examined the gene transfer efficiency and toxicity of 2-kDa polyethylenimine conjugated to gold nanoparticles (PEI2-GNP) in the human cornea in vitro and rabbit cornea in vivo. PEI2-GNP with nitrogen-to-phosphorus (N/P) ratios of up to 180 exhibited significant transgene delivery in the h...

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Main Authors: Sharma, Ajay, Tandon, Ashish, Tovey, Jonathan C. K., Gupta, Rangan, Robertson, J. David, Fortune, Jennifer A., Klibanov, Alexander M., Cowden, John W., Rieger, Frank G., Mohan, Rajiv R.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094737/
https://ncbi.nlm.nih.gov/pubmed/21272669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2011.01.006
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