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Deprotection of methylphosphonate oligonucleotides using a novel one-pot procedure.
Deprotection of methylphosphonate oligonucleotides with ethylenediamine was evaluated in a model system. Methylphosphonate sequences of the form 5'-TTTNNTTT, where N was either N4-bz-dC, N4-ibu-dC, N2-ibu-O6-DPC-dG, N2-ibu-dG, N6-bz-dA, or T, were used to determine the extent of modifications t...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1993
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| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8502543/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.9.2031 |
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