Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA Sequences

BACKGROUND: Replication of mammalian genomes requires the activation of thousands of origins which are both spatially and temporally regulated by as yet unknown mechanisms. At the most fundamental level, our knowledge about the distribution pattern of origins in each of the chromosomes, among differ...

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Bibliographic Details
Main Authors: Valenzuela, Manuel S., Chen, Yidong, Davis, Sean, Yang, Fan, Walker, Robert L., Bilke, Sven, Lueders, John, Martin, Melvenia M., Aladjem, Mirit I., Massion, Pierre P., Meltzer, Paul S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094316/
https://ncbi.nlm.nih.gov/pubmed/21602917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017308
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