Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA Sequences

BACKGROUND: Replication of mammalian genomes requires the activation of thousands of origins which are both spatially and temporally regulated by as yet unknown mechanisms. At the most fundamental level, our knowledge about the distribution pattern of origins in each of the chromosomes, among differ...

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Detalhes bibliográficos
Main Authors: Valenzuela, Manuel S., Chen, Yidong, Davis, Sean, Yang, Fan, Walker, Robert L., Bilke, Sven, Lueders, John, Martin, Melvenia M., Aladjem, Mirit I., Massion, Pierre P., Meltzer, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094316/
https://ncbi.nlm.nih.gov/pubmed/21602917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017308
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