Thermal stability of DNA adducts induced by cyanomorpholinoadriamycin in vitro.
The Adriamycin derivative, cyanomorpholinoadriamycin (CMA) was reacted with DNA in vitro to form apparent interstrand crosslinks. The extent of interstrand crosslink formation was monitored by a gel electrophoresis assay and maximal crosslinking of DNA was observed within 1 hr with 5 microM of drug....
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
1993
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| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309425/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8493102/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.8.1857 |
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