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Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2

AMBRA1 and Bcl-2 both interact with Beclin 1 and control autophagy as a positive or negative regulator, respectively. A paper in this issue reveals an interaction between AMBRA1 and Bcl-2 at the mitochondrial outer membrane that is relieved upon induction of autophagy or apoptosis allowing AMBRA1 to...

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Bibliografiske detaljer
Main Authors: Tooze, Sharon A, Codogno, Patrice
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094128/
https://ncbi.nlm.nih.gov/pubmed/21468095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.75
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