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Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2
AMBRA1 and Bcl-2 both interact with Beclin 1 and control autophagy as a positive or negative regulator, respectively. A paper in this issue reveals an interaction between AMBRA1 and Bcl-2 at the mitochondrial outer membrane that is relieved upon induction of autophagy or apoptosis allowing AMBRA1 to...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Nature Publishing Group
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3094128/ https://ncbi.nlm.nih.gov/pubmed/21468095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.75 |
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