Thermodynamic stability and drug-binding properties of oligodeoxyribonucleotide duplexes containing 3-deazaadenine:thymine base pairs.

We have used ultraviolet melting techniques to study the effect on stability of incorporating the nucleoside analogue 2'-deoxy-3-deazaadenosine (d3cA) into the duplex 5'-d(CGCAATCG)-3'-d(GCGTTAGC). Our results demonstrate that the successive replacement of dA by d3CA increasingly destabilises the du...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Lever, C, Li, X, Cosstick, R, Ebel, S, Brown, T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1993
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309409/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8493091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.8.1743
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