Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys

Objectives. To characterize the in vitro binding and effector function properties of CD20-directed small modular immunopharmaceutical (SMIP) 2LM20-4, and to compare its in vivo B-cell depletion activity with the mutated 2LM20-4 P331S [no in vitro complement-dependent cytotoxicity (CDC)] and rituxima...

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Detaylı Bibliyografya
Asıl Yazarlar: Nickerson-Nutter, Cheryl, Tchistiakova, Lioudmila, Seth, Nilufer P., Kasaian, Marion, Sibley, Barbara, Olland, Stephane, Zollner, Richard, Brady, William A., Mohler, Kendall M., Baum, Peter, Wahl, Alan, Herber, Deborah, Vugmeyster, Yulia, Wensel, David, Wolfman, Neil M., Gill, Davinder, Collins, Mary, Dunussi-Joannopoulos, Kyri
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
Konular:
Basic Science
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093928/
https://ncbi.nlm.nih.gov/pubmed/21258049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keq423
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