Host Protein Ku70 Binds and Protects HIV-1 Integrase from Proteasomal Degradation and Is Required for HIV Replication

HIV-1 integrase (IN) is a key viral enzymatic protein acting in several viral replication steps, including integration. IN has been shown to be an unstable protein degraded by the N-end rule pathway through the host ubiquitin-proteasome machinery. However, it is still not fully understood how this v...

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Bibliografiska uppgifter
Huvudupphovsmän: Zheng, Yingfeng, Ao, Zhujun, Wang, Binchen, Jayappa, Kallesh Danappa, Yao, Xiaojian
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093848/
https://ncbi.nlm.nih.gov/pubmed/21454661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184739
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