The E3 Ubiquitin Ligase- and Protein Phosphatase 2A (PP2A)-binding Domains of the Alpha4 Protein Are Both Required for Alpha4 to Inhibit PP2A Degradation

Protein phosphatase 2A (PP2A) is regulated through a variety of mechanisms, including post-translational modifications and association with regulatory proteins. Alpha4 is one such regulatory protein that binds the PP2A catalytic subunit (PP2Ac) and protects it from polyubiquitination and degradation...

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Main Authors: LeNoue-Newton, Michele, Watkins, Guy R., Zou, Ping, Germane, Katherine L., McCorvey, Lisa R., Wadzinski, Brian E., Spiller, Benjamin W.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
Signal Transduction
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093842/
https://ncbi.nlm.nih.gov/pubmed/21454489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222414
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