Potent Inhibitors of a Shikimate Pathway Enzyme from Mycobacterium tuberculosis: COMBINING MECHANISM- AND MODELING-BASED DESIGN

Tuberculosis remains a serious global health threat, with the emergence of multidrug-resistant strains highlighting the urgent need for novel antituberculosis drugs. The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) catalyzes the first step of the shikimate pathway for the bio...

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Detalhes bibliográficos
Main Authors: Reichau, Sebastian, Jiao, Wanting, Walker, Scott R., Hutton, Richard D., Baker, Edward N., Parker, Emily J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093739/
https://ncbi.nlm.nih.gov/pubmed/21454647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211649
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