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Variable effects of the conserved RNA hairpin element upon 3' end processing of histone pre-mRNA in vitro.

We have studied the requirements for efficient histone-specific RNA 3' processing in nuclear extract from mammalian tissue culture cells. Processing is strongly impaired by mutations in the pre-mRNA spacer element that reduce the base-pairing potential with U7 RNA. Moreover, by exchanging the h...

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Bibliographic Details
Main Authors: Streit, A, Koning, T W, Soldati, D, Melin, L, Schümperli, D
Format: Artigo
Language:Inglês
Published: 1993
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC309364/
https://ncbi.nlm.nih.gov/pubmed/8479907
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