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The effects of terminal heterologies on gene targeting by insertion vectors in embryonic stem cells.
We have examined the effects of placing nonhomologous DNA on the ends of an insertion-type gene targeting vector. The presence of terminal heterologies was found to be compatible with insertion targeting, and the terminal heterologies were efficiently removed. Terminal heterologies reduced the frequ...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
1993
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC309360/ https://ncbi.nlm.nih.gov/pubmed/8386835 |
| Etykiety: |
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