The Molecular Basis for Antimicrobial Activity of Pore-Forming Cyclic Peptides

The mechanism of action of antimicrobial peptides is, to our knowledge, still poorly understood. To probe the biophysical characteristics that confer activity, we present here a molecular-dynamics and biophysical study of a cyclic antimicrobial peptide and its inactive linear analog. In the simulati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cirac, Anna D., Moiset, Gemma, Mika, Jacek T., Koçer, Armagan, Salvador, Pedro, Poolman, Bert, Marrink, Siewert J., Sengupta, Durba
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2011
Schlagworte:
Membrane
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093570/
https://ncbi.nlm.nih.gov/pubmed/21575576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.03.057
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