Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction

Grb2 (growth-factor receptor-bound protein-2) is a signaling adaptor that interacts with numerous receptors and intracellular signaling molecules. However, its role in B-cell development and function remains unknown. Here we show that ablation of Grb2 in B cells results in enhanced B-cell receptor s...

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Main Authors: Jang, Ihn Kyung, Cronshaw, Darran G., Xie, Luo-kun, Fang, Guoqiang, Zhang, Jinping, Oh, Hyunju, Fu, Yang-Xin, Gu, Hua, Zou, Yongrui
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093453/
https://ncbi.nlm.nih.gov/pubmed/21508326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016451108
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