Wordt geladen...
Grb2 functions at the top of the T-cell antigen receptor–induced tyrosine kinase cascade to control thymic selection
Grb2 is an adaptor molecule that mediates Ras-MAPK activation induced by various receptors. Here we show that conditional ablation of Grb2 in thymocytes severely impairs both thymic positive and negative selections. Strikingly, the mutation attenuates T-cell antigen receptor (TCR) proximal signaling...
Bewaard in:
| Hoofdauteurs: | , , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2010
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890815/ https://ncbi.nlm.nih.gov/pubmed/20498059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905039107 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|