Grb2 functions at the top of the T-cell antigen receptor–induced tyrosine kinase cascade to control thymic selection

Grb2 is an adaptor molecule that mediates Ras-MAPK activation induced by various receptors. Here we show that conditional ablation of Grb2 in thymocytes severely impairs both thymic positive and negative selections. Strikingly, the mutation attenuates T-cell antigen receptor (TCR) proximal signaling...

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Detalles Bibliográficos
Main Authors: Jang, Ihn Kyung, Zhang, Jinping, Chiang, Yungping J., Kole, Hemanta K., Cronshaw, Darran G., Zou, Yongrui, Gu, Hua
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890815/
https://ncbi.nlm.nih.gov/pubmed/20498059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905039107
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