Cancer Screening by Systemic Administration of a Gene Delivery Vector Encoding Tumor-Selective Secretable Biomarker Expression

Cancer biomarkers facilitate screening and early detection but are known for only a few cancer types. We demonstrated the principle of inducing tumors to secrete a serum biomarker using a systemically administered gene delivery vector that targets tumors for selective expression of an engineered cas...

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Bibliographic Details
Main Authors: Browne, Andrew W., Leddon, Jennifer L., Currier, Mark A., Williams, Jon P., Frischer, Jason S., Collins, Margaret H., Ahn, Chong H., Cripe, Timothy P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092745/
https://ncbi.nlm.nih.gov/pubmed/21589655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019530
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