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Species Differences in the Pharmacology and Toxicology of PEGylated Helper-Dependent Adenovirus
Clinically relevant doses of helper-dependent adenoviruses (HDAds) provoke the host response against capsid proteins in primates and rodents. To determine if PEGylation truly affects this, baboons and mice were given either HDAd or PEG-HDAd expressing beta-galactosidase at 5 × 10(11) or 3 × 10(12) v...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092739/ https://ncbi.nlm.nih.gov/pubmed/20822161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100216h |
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