Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome

In light with the view that KEAP1 loss of function may impact tumor behavior and modify response to chemotherapeutical agents, we sought to determine whether KEAP1 gene is epigenetically regulated in malignant gliomas. We developed a Quantitative Methylation Specific PCR (QMSP) assay to analyze 86 m...

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Main Authors: Muscarella, Lucia Anna, Barbano, Raffaela, D'Angelo, Vincenzo, Copetti, Massimiliano, Coco, Michelina, Balsamo, Teresa, la Torre, Annamaria, Notarangelo, Angelo, Troiano, Michele, Parisi, Salvatore, Icolaro, Nadia, Catapano, Domenico, Valori, Vanna Maria, Pellegrini, Fabio, Merla, Giuseppe, Carella, Massimo, Fazio, Vito Michele, Parrella, Paola
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092680/
https://ncbi.nlm.nih.gov/pubmed/21173573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.6.3.14408
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