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Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology
The role of direct IL-10 signaling in different T cell subsets is not well understood. To address this, we generated transgenic mice expressing a dominant-negative IL-10 receptor specifically in T cells (CD4dnIL-10Rα). We found that Foxp3-depleted CD45RB(lo) (regulatory T cell [T(reg) cell]–depleted...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092344/ https://ncbi.nlm.nih.gov/pubmed/21518800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102149 |
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