Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology

The role of direct IL-10 signaling in different T cell subsets is not well understood. To address this, we generated transgenic mice expressing a dominant-negative IL-10 receptor specifically in T cells (CD4dnIL-10Rα). We found that Foxp3-depleted CD45RB(lo) (regulatory T cell [T(reg) cell]–depleted...

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Detalhes bibliográficos
Main Authors: Kamanaka, Masahito, Huber, Samuel, Zenewicz, Lauren A., Gagliani, Nicola, Rathinam, Chozhavendan, O'Connor, William, Wan, Yisong Y., Nakae, Susumu, Iwakura, Yoichiro, Hao, Liming, Flavell, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092344/
https://ncbi.nlm.nih.gov/pubmed/21518800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102149
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