MET Inhibition Results in DNA Breaks and Synergistically Sensitizes Tumor Cells to DNA-Damaging Agents Potentially by Breaching a Damage-Induced Checkpoint Arrest

While recent studies implicate that signaling through the receptor tyrosine kinase MET protects cancer cells from DNA damage, molecular events linking MET to the DNA damage response machinery are largely unknown. Here, we studied the impact of MET inhibition by the small molecule PHA665752 on cytoto...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Medová, Michaela, Aebersold, Daniel Matthias, Blank-Liss, Wieslawa, Streit, Bruno, Medo, Matúš, Aebi, Stefan, Zimmer, Yitzhak
Format: Artigo
Langue:Inglês
Publié: SAGE Publications 2010
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092265/
https://ncbi.nlm.nih.gov/pubmed/21779429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910388030
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