MET Inhibition Results in DNA Breaks and Synergistically Sensitizes Tumor Cells to DNA-Damaging Agents Potentially by Breaching a Damage-Induced Checkpoint Arrest

While recent studies implicate that signaling through the receptor tyrosine kinase MET protects cancer cells from DNA damage, molecular events linking MET to the DNA damage response machinery are largely unknown. Here, we studied the impact of MET inhibition by the small molecule PHA665752 on cytoto...

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Bibliografiske detaljer
Main Authors: Medová, Michaela, Aebersold, Daniel Matthias, Blank-Liss, Wieslawa, Streit, Bruno, Medo, Matúš, Aebi, Stefan, Zimmer, Yitzhak
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2010
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092265/
https://ncbi.nlm.nih.gov/pubmed/21779429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910388030
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