BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression

Increasing evidence suggests that processes termed epithelial-mesenchymal transitions (EMTs) play a key role in therapeutic resistance, tumor recurrence, and metastatic progression. NF-κB signaling has been previously identified as an important pathway in the regulation of EMT in a mouse model of tu...

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Main Authors: Huber, Margit A., Maier, Harald J., Alacakaptan, Memetcan, Wiedemann, Eva, Braunger, Jürgen, Boehmelt, Guido, Madwed, Jeffrey B., Young, Erick R.R., Marshall, Daniel R., Pehamberger, Hubert, Wirth, Thomas, Kraut, Norbert, Beug, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2010
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092186/
https://ncbi.nlm.nih.gov/pubmed/21779445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910361749
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