BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression

Increasing evidence suggests that processes termed epithelial-mesenchymal transitions (EMTs) play a key role in therapeutic resistance, tumor recurrence, and metastatic progression. NF-κB signaling has been previously identified as an important pathway in the regulation of EMT in a mouse model of tu...

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Hlavní autoři: Huber, Margit A., Maier, Harald J., Alacakaptan, Memetcan, Wiedemann, Eva, Braunger, Jürgen, Boehmelt, Guido, Madwed, Jeffrey B., Young, Erick R.R., Marshall, Daniel R., Pehamberger, Hubert, Wirth, Thomas, Kraut, Norbert, Beug, Hartmut
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2010
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092186/
https://ncbi.nlm.nih.gov/pubmed/21779445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910361749
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