Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas

Bcl-2 proteins represent a rheostat that controls cellular viability. Obatoclax, a BH3-mimetic, has been designed to specifically target and counteract anti-apoptotic Bcl-2 proteins. We evaluated the biological effects of obatoclax on the anti-tumour activity of rituximab and chemotherapy agents. Ob...

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Hlavní autoři: Brem, Elizabeth A., Thudium, Karen, Khubchandani, Sapna, Tsai, Ping-Chiao, Olejniczak, Scott H., Bhat, Seema, Riaz, Wasif, Gu, Jenny, Iqbal, Arshad, Campagna, Ryan, Knight, Joy, Mavis, Cory, Hoskin, Paul, Deeb, George, Gibbs, John F., Fetterly, Gerald, Czuczman, Myron S., Hernandez-Ilizaliturri, Francisco J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092002/
https://ncbi.nlm.nih.gov/pubmed/21492126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2011.08669.x
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