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Regulating ProNGF Action: Multiple targets for therapeutic intervention
Neurotrophins are initially synthesized as precursor forms, that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a rece...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091386/ https://ncbi.nlm.nih.gov/pubmed/19526280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-009-9054-9 |
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