Suppression of Latent Transforming Growth Factor (TGF)-β1 Restores Growth Inhibitory TGF-β Signaling through microRNAs

Cancer cells secreting excess latent TGF-β are often resistant to TGF-β induced growth inhibition. We observed that RNAi against TGF-β1 led to apoptotic death in such cell lines with features that were, paradoxically, reminiscent of TGF-β signaling activity and that included transiently enhanced SMA...

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Bibliographic Details
Main Authors: Dogar, Afzal M., Towbin, Harry, Hall, Jonathan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091250/
https://ncbi.nlm.nih.gov/pubmed/21402698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208652
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