A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells

Enzymes of the phosphodiesterase 3 (PDE3) and PDE4 families each regulate the activities of both protein kinases A (PKAs) and exchange proteins activated by cAMP (EPACs) in cells of the cardiovascular system. At present, the mechanisms that allow selected PDEs to individually regulate the activities...

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Detalhes bibliográficos
Main Authors: Wilson, Lindsay S., Baillie, George S., Pritchard, Lisa M., Umana, Bibiana, Terrin, Anna, Zaccolo, Manuela, Houslay, Miles D., Maurice, Donald H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091235/
https://ncbi.nlm.nih.gov/pubmed/21393242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217026
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