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Proteolytic Processing of Angiopoietin-like Protein 4 by Proprotein Convertases Modulates Its Inhibitory Effects on Lipoprotein Lipase Activity

Angiopoietin-like protein 4 (ANGPTL4) has been associated with a variety of diseases. It is known as an endogenous inhibitor of lipoprotein lipase (LPL), and it modulates lipid deposition and energy homeostasis. ANGPTL4 is cleaved by unidentified protease(s), and the biological importance of this cl...

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Autors principals: Lei, Xia, Shi, Fujun, Basu, Debapriya, Huq, Afroza, Routhier, Sophie, Day, Robert, Jin, Weijun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091183/
https://ncbi.nlm.nih.gov/pubmed/21398697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217638
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