The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms.

The promoter regions of three IL-6 inducible genes, hemopexin (Hpx), haptoglobin (Hp) and C-reactive protein (CRP) contain cis-acting IL-6 responsive elements (IL-6REs) which are necessary and sufficient to induce IL-6 transcription activation. Transcription factors of the C/EBP family interact with...

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Autores principales: Ramji, D P, Vitelli, A, Tronche, F, Cortese, R, Ciliberto, G
Formato: Artigo
Lenguaje:Inglês
Publicado: 1993
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC309105/
https://ncbi.nlm.nih.gov/pubmed/7680115
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