Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung

It remains unknown whether tobacco smoke induces DNA hypermethylation as an early event in carcinogenesis or as a late event, specific to overt cancer tissue. Using MethyLight assays, we analyzed 316 lung tissue samples from 151 cancer-free subjects (121 ever-smokers and 30 never-smokers) for hyperm...

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Autors principals: Salskov, Alexander, Hawes, Stephen E., Stern, Joshua E., Feng, Qinghua, Jordan, C. Diana, Wiens, Linda, Rasey, Janet, Lu, Hiep, Kiviat, Nancy B., Vesselle, Hubert
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090638/
https://ncbi.nlm.nih.gov/pubmed/21577262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/950140
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