Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation

BACKGROUND: Apoptosis, neuroinflammation and blood-brain barrier (BBB) damage affect the susceptibility of the developing brain to hypoxic-ischemic (HI) insults. c-Jun N-terminal kinase (JNK) is an important mediator of insulin resistance in obesity. We hypothesized that neonatal overweight aggravat...

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Huvudupphovsmän: Tu, Yi-Fang, Tsai, Yau-Sheng, Wang, Lan-Wan, Wu, Hsin-Chieh, Huang, Chao-Ching, Ho, Chien-Jung
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2011
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090337/
https://ncbi.nlm.nih.gov/pubmed/21518436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-40
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