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Coupled 5′ nucleotide recognition and processivity in Xrn1-mediated mRNA decay
Messenger RNA decay plays a central role in the regulation and surveillance of eukaryotic gene expression. The conserved multi-domain exoribonuclease Xrn1 targets cytoplasmic RNA substrates marked by a 5′ monophosphate for processive 5′-to-3′ degradation by an unknown mechanism. Here we report the c...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3090138/ https://ncbi.nlm.nih.gov/pubmed/21362555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.004 |
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