CYP2C19 Variation and Citalopram Response

OBJECTIVE: Variations in cytochrome P450 (CYP) genes have been shown to be associated with both accelerated and delayed pharmacokinetic clearance of many psychotropic medications. Citalopram is metabolized by three CYP enzymes. CYP2C19 and CYP3A4 play a primary role in citalopram metabolism, whereas...

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Hauptverfasser: Mrazek, David A., Biernacka, Joanna M., O'Kane, Dennis J., Black, John L., Cunningham, Julie M., Drews, Maureen S., Snyder, Karen A., Stevens, Susanna R., Rush, Augustus John, Weinshilboum, Richard M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090085/
https://ncbi.nlm.nih.gov/pubmed/21192344
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