Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway

Glioma stem-cells are associated with the brain vasculature. However, the way in which this vascular niche regulates stem-cell renewal and fate remains unclear. Here, we show that factors emanating from brain endothelial cells positively control the expansion of long-term glioblastoma stem-like cell...

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Detalhes bibliográficos
Main Authors: Galan-Moya, Eva Maria, Le Guelte, Armelle, Fernandes, Evelyne Lima, Thirant, Cécile, Dwyer, Julie, Bidere, Nicolas, Couraud, Pierre-Olivier, Scott, Mark G H, Junier, Marie-Pierre, Chneiweiss, Hervé, Gavard, Julie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090013/
https://ncbi.nlm.nih.gov/pubmed/21460795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.39
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